Sergio Peignier

Gene Regulatory Network Inference

Advanced course on modeling and inferring gene regulatory networks from transcriptomic data, combining machine learning, systems biology, and data-driven approaches.

Focus: Systems Biology · Machine Learning · Network Inference · Transcriptomics

Level: Advanced / Graduate / Research

Regulation in Biological Systems

Introduction to gene regulation mechanisms and biological network structures.

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Gene Regulatory Network Inference Methods

Overview of computational approaches to infer gene regulatory networks from expression data.

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GRN Inference using Machine Learning

Application of classification-based models for reconstructing gene regulatory interactions.

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Project: GRN Inference in Drosophila Eye Development

Hands-on project exploring gene regulatory interactions in developmental biology using real datasets.

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Sequence Analysis & String Algorithms

Computational methods for genomic sequence analysis, including string matching, alignment algorithms, suffix structures, and probabilistic models for biological sequences.

Focus: Genomics · String Algorithms · Sequence Alignment · Computational Biology

Level: Advanced Undergraduate / Graduate

Introduction to Genomics

Overview of computational genomics and sequence-based biological data analysis.

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Sequence Alignment

Algorithms for comparing biological sequences and identifying similarities.

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String Distance & Alignment

Computational methods for measuring similarity between biological sequences.

Notebook
Solutions

Levenshtein Distance

Edit distance metrics for sequence comparison and mutation modeling.

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Suffix Arrays

Efficient data structures for fast substring search in genomic sequences.

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Burrows–Wheeler Transform (BWT)

Compression and indexing technique widely used in genomic alignment tools.

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Notebook

BWT Tutorial

Hands-on implementation of the Burrows–Wheeler transform and applications.

Notebook
Solutions

RNA Secondary Structure Prediction

Computational prediction of RNA folding and structural stability.

Notebook

Naive Genomics Models

Basic probabilistic and heuristic models for genomic sequence analysis.

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Neutral Networks in Sequence Space

Exploration of evolutionary landscapes using sequence-based neutral models.

Notebook

Association-Based Sequence Analysis

Statistical approaches for identifying patterns and associations in genomic data.

Notebook